5-氮杂-2′-脱氧胞苷

5-氮杂-2′-脱氧胞苷

5-氮杂-2′-脱氧胞苷

性质

Related Categories AN-AZ, Approved Therapeutics/Drug Candidates,Bioactive Small Molecule Alphabetical Index, Eisai,Fluorination Ready Pharma-Developed Compounds,
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InChI Key   XAUDJQYHKZQPEU-KVQBGUIXSA-N
assay   ≥97%
solubility   acetic acid: water (1:1): 50 mg/mL
originator   Eisai

产品描述

包装

5, 10 mg in glass bottle

50 mg in glass insert

Application

5-Aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, DNA and promoter region of p16 gene.[3][4][5][6]

Biochem/physiol Actions

5′-脱氧杂氮胞苷可引起DNA去甲基化或半去甲基化。DNA去甲基化可通过随着提高的核酸酶活性而“打开”染色质的结构来调控基因的表达。这种染色质结构的重塑可实现转录因子与启动子区域的结合、转录复合物的组装及基因表达。

Features and Benefits

该化合物是基因调控研究的特色产品。点击此处以了解更多的基因调控特色产品。

该化合物由Eisai开发。

5-Aza-2′-deoxycytidine is a DNA-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.[1] It is a 2′-deoxycytidine analogue.[2] 5-Aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.